Research - Creatine Vol. 4: Other Health Benefits

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Research - Creatine Vol. 4: Other Health Benefits

Postby Canuck Singh » Wed Jul 23, 2008 5:22 pm

Found in the blood, high levels of homocysteine are linked directly to increased incidence of cardiovascular disease, including heart attacks and strokes and this link is particularly high in men. We appear to produce more of this compound as we age.

Now, a study of 650 healthy Italians over aged 65, reveal a good correlation between high plasma homocysteine levels and poor cognitive function. This results of this study point to a direct detrimental effect of elevated homocysteine on the brain during the aging process. So how can we lower our homocysteine levels and protect our selves against its detrimental effects?

Some research has shown that homocysteine levels can be lowered by supplementation with vitamin B12, folate, and vitamin B6. However, an insightful medical paper presented by Dr. M.F. McCarty suggests that daily creatine supplementation would suppress normal creatine synthesis, thereby inhibiting a major production process of homocysteine.

Creatine supplementation may be practical strategy for decreasing homocysteine levels, thereby decreasing the risk of heart disease and a decline in mental capacity. This is just another good reason to take your creatine. And you thought creatine was only for big muscles!
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Re: Research - Creatine Vol. 4: Other Health Benefits

Postby Canuck Singh » Wed Oct 01, 2008 10:21 pm

Micronized Creatine monohydrate is the most effective muscle-building, performance enhancing supplement ever. However, the results of a new study have shown that creatine monohydrate also acts as an antioxidant that protects cells against free radical damage that cause premature ageing and death.

The new study is the first to look at the effect of creatine monohydrate on human cell cultures exposed to a range of oxidizing agents, such as hydrogen peroxide and tert-butylhydroperoxide. At concentrations comparable to those attainable in plasma after oral supplementation, creatine exerted direct antioxidant activity in cultured mammalian cells exposed to the oxidizing agents.

Excessive production of free radicals causes oxidative stress that damage cells and cause premature ageing. The data from this study suggests that creatine monohydrate acts as a direct antioxidant by scavenging free radicals. The researchers found that the presence of creatine in the cell cultures boosted the percentage survival of cells by more than 20% compared to cells exposed to oxidizing agents without creatine.

Supplementation with creatine monohydrate is shown in research to be a safe and highly effective supplement that enhances strength and muscle growth during weight training exercise. Certain organs in the body, such as the heart and brain are sensitive to oxidative damage. Therefore, regular supplementation with creatine monohydrate during exercise would not only speed muscle and strength development it would also help protect these vital organs against oxidative damage that causes premature ageing.

Source: Free Radical Biology and Medicine 40;837-849, 2006.
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Re: Research - Creatine Vol. 4: Other Health Benefits

Postby Canuck Singh » Sat Oct 04, 2008 11:06 pm

a recent study has shown that supplementation with Micronized Creatine monohydrate improves the ability of the muscle to maintain energy balance during intense aerobic exercise.

Seven well-trained men completed two experimental trials involving approximately 1 hour of intense endurance exercise (cycling 45 min at 78 VO2max). This was followed by a shorter (13 minute) performance ride. Results showed that despite the performance ride times being similar, when the men were given creatine (as compared to a placebo) their muscle inosine monophosphate (IMP) were significantly lower after the exercise.

IMP is a by-product of energy (ATP) breakdown that occurs only during intense exercise. Increasing muscle creatine via supplementation before exercise appeared to improve the ability of the muscle to regenerate ATP more effectively during intense aerobic exercise. A reduction in the amount of IMP produced after intense exercise would also promote faster recovery and better energy restoration for the next workout.

Source: Medicine & Science in Sports & Exercise, 37; 2054-2061, 2006
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Re: Research - Creatine Vol. 4: Other Health Benefits

Postby Canuck Singh » Thu Oct 16, 2008 8:06 pm

If you exercise or compete in hot or humid environments, creatine monohydrate is one supplement that may be of great benefit. It may even give you an edge over your competition.

This study determined the effects loading with creatine monohydrate on thermoregulatory responses within the body during intense exercise in a hot/humid environment. Ten heat-acclimatized athletes performed several sprint cycling workouts after 6 days of loading with creatine and a placebo.

The workouts were completed in a heat chamber at 37 degrees Celsius (almost 100 degrees Fahrenheit). Results showed that peak power and mean power output were significantly higher after supplementation with creatine monohydrate. Also, supplementation did not produce any different thermoregulatory responses when compared to the placebo. This led the researchers to conclude that supplementation with creatine monohydrate does not cause any heat-stress related problems but it does enhance exercise performance in the heat.

If you exercise or compete in hot or humid environments, creatine monohydrate may give you an edge in terms of hydration and performance. Creatine loading promotes better cell hydration by increasing the muscle’s ability to hold water. Increased water content in tissues would be beneficial for maintaining hydration status and core temperature when training or competing in the heat.

Source: J. Strength Cond. Res. 21(3):655–660. 2007
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Re: Research - Creatine Vol. 4: Other Health Benefits

Postby Canuck Singh » Mon Nov 10, 2008 7:58 pm

Many people don't realize that creatine supplementation is documented to provided very favorable out comes in many clinical conditions. Regarding some neural myopathies, oral creatine supplements have been shown to regenerate the mylen sheath nerve endings that are essential to healthy nerve function. In many of the more common muscular dystrophies, creatine is shown to help regenerate myotublues and calcium regulation in muscle.

Creatine supplementation has been reported to improve the lipid profiles of middle age male and females with elevated triglyceride blood levels. Significant reductions in total cholesterol and blood fats (triglycerides) were seen after only 56 days of supplementation (Clinical Science 91:1996).

Recently, creatine supplementation was shown to improve the health and muscular strength of chronic heart failure patients (European Journal of Heart Surgery 19:1998). These people were given 5gms of creatine a day, 4 times a day for 5 days. In this short period of time the patients exhibited more muscle strength and greater muscular endurance. This is important as a major side effect of heart failure is chronic muscle weakness and lethargy. Therefore creatine is now recommended to heart patients to help with recovery, improve strength and endurance and to be able to live a more normal life
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