Research - Conjugated Linoleic Acid: CLA

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Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Sat Jun 07, 2008 9:16 am

CLA
This study once again proved CLA's potent cancer preventative effects. This study demonstrated that some types of CLA supplements are definitely better than others. The incorporation of a specific c9t11 isomer appears to be critical. This type of CLA was clearly shown to be a very biologically active anti-carcinogen compound. It reduced mammary cancer risk in rats by decreasing the cancer cells target population and lowered the level of turnover of these target cells.

In this study, various types of CLA compounds were fed to rats. The supplement that was high in the c9t11 isomer produced significantly higher tissue levels of CLA.

The presence of this particular type of CLA molecule is critical to obtaining this supplements potent benefits. Most CLA supplements used in research do not contain any of it! Make sure you read the label of your CLA supplement, if it doesn’t say it contains the specific c9 t11 CLA isomer ditch it! You are not getting the full benefits of CLA.

Ref: Conjugated Linoleic Acid-Enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. J.Nutr.129:2135-2142 1999.
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Tue Jul 15, 2008 3:33 pm

Conjugated linoleic acid (CLA) is fast becoming one of the most effective supplements for improving body composition. While it appears to be a safe and effective supplement for decreasing fat mass and increasing lean mass, scientists are still not sure exactly how CLA causes these remarkable results.

Scientists from the Unliver Research Institute in the Netherlands exposed fats cell (within test tubes) to a variety of substances, one of them was CLA, and examined the effects. The researchers found that CLA increased the activity of an enzyme called lipoprotein lipase - the enzyme that breaks down and mobilizes fat from fat cells. This research is the first to examine the mechanisms behind CLA's remarkable ability to reduce body fat.

Ref: J. Nutr Biochem. 12: 183-189, 2001
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Mon Jul 21, 2008 2:24 pm

Another study demonstrating the fat loss benefits of CLA has recently been published (The Journal of Nutrition. 133: 257S-260S, 2003). Prior research with CLA has shown a clear reduction in adipose (fat) mass in various mammals, as well as overweight humans, while CLA is also shown to delay the onset of diabetes and improve glucose metabolism.

The researchers involved in this study wanted to examine if CLA supplementation (8 grams per day) would enhance fat loss in a group of people with type 2 diabetes mellitus.

In this double-blind study, subjects with type 2 diabetes were randomized into one of two groups receiving CLA isomers or a supplement containing safflower oil for an eight-week period. The findings revealed CLA supplementation, particularly with the t10c12-CLA isomer, caused significant changes in body composition. The data from this research strongly suggests that the t10c12-CLA isomer may be the bioactive isomer of CLA to influence the body weight changes. Future studies are needed to determine the optimal ratio of the most bioactive CLA isomers, but one thing is for sure – CLA is quickly emerging as a potent supplement for enhancing gains in lean mass and loss of body fat.

Ref: J. Nutr. 133: 257S-260S 2003.
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Mon Jul 21, 2008 2:25 pm

A study published in the January 2003 issue of the Journal of Nutrition showed that supplementing with CLA for 8 weeks had a five times lower blood sugar level than those taking the safflower placebo. Researchers also found that higher levels of CLA in the bloodstream correlated with lower levels of leptin, a hormone thought to regulate fat levels. It’s believed that high leptin levels may play a role in obesity; which is one of the greatest risk factors for adult-onset diabetes. Obesity is also responsible for over 300,000 deaths each year in the US.

Researchers also concluded that the longer CLA is taken the more effective it was at reducing blood sugar and weight.

This adds to CLA’s growing list of scientific research studies showing benefits in:
    cancer protection
    positive body composition changes
    lowered body fat
    and lowered cholesterol and triglycerides.
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Thu Aug 21, 2008 5:55 am

A new long-term study by Norwegian scientists has confirmed that CLA is a potent supplement for burning fat and building muscle.

In a year-long study, the researchers from the Scandinavian Clinical Research Centre, Norway, found that the subjects who added CLA to their daily diet reduced their body fat by an impressive 9.6%. At the same time, their lean mass increased by 1.9%! The dosage used was 3-5 grams per day.

The evidence for CLA’s powerful effects on improving body composition just keeps getting stronger. Almost 12 studies in the last 3 years have revealed that CLA helps to burn unwanted fat while adding lean tissue. Best of all, no unwanted side effects are reported from taking CLA.

Experimental Biology Meeting, May, 2003.

* Have you ever tasted CLA liquid? Eyuck
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Wed Aug 27, 2008 4:56 am

A recent, year-long study on the fat loss effects of Conjugated linoleic acid (CLA) has revealed that CLA significantly reduced body fat in overweight, but otherwise healthy, adults by as much as nine percent.

In this study, one hundred and eighty healthy men and women volunteers, ages 18 to 65, with a body mass index (BMI) of 25-30 kg/m2 (indicating that they were overweight) were randomized to receive gel capsules containing either 3.4 grams CLA-free fatty acid or 3.4 grams CLA-triglycerides or equivalent amounts of olive oil (placebo). Patients were then followed for 12 months. Weight, BMI, vital signs and adverse events were recorded every three months. Body composition and blood samples were analyzed at regular intervals throughout the study, and participants were monitored continuously for any signs of serious adverse events.

After only six months of observation, individuals taking either form of CLA experienced a significant reduction in body fat mass, while those in the placebo group saw no change. Daily caloric intake and exercise was not different between groups and didn’t change throughout the 12 month period. The researchers concluded that the body composition changes observed in the CLA groups were directly due to supplementation with CLA. No major adverse effects were reported.

The randomized, double blind, placebo-controlled study confirms the long-term safety and efficacy of CLA supplementation for fat loss. Just 3-4 grams a day of CLA safely improves body composition by reducing fat and preserving lean muscle tissue.

American Journal of Clinical Nutrition, 2004; 79(6):1118-1125)
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Wed Aug 27, 2008 5:14 am

Recent scientific reviews show that the compound conjugated linoleic acid (CLA) has anticancer properties, is able to improve immune function, carbohydrate metabolism (to help prevent body fat accumulation) as well as enhance fat loss. These benefits make CLA one of the most important supplements available to bodybuilders. The purpose of a recently published review was to examine the research behind CLA’s ability to reduce body fat levels and improve insulin sensitivity in muscle.

The research review showed that either specific CLA isomers or mixtures of CLA isomers are able to lower body fat and enhance insulin sensitivity in animals and humans. Insulin is a key hormone that is responsible for transporting nutrients into muscle cells and improving insulin sensitivity in all tissues ensures more nutrients are transported into muscle to speed results from training.

An isomer is simply a different molecular arrangement of the same compound, and there are several different isomers of CLA. Until science proves conclusively that one CLA isomer is better than another it’s probably best to use a CLA supplement that contains a mix of CLA isomers.

J. Nutr. 133:3041-3046, 2003
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Tue Sep 02, 2008 4:21 am

This research is getting so compelling!

Over 60% of American adults are overweight. Almost every month it seems as though another study shows CLA’s positive effect on fat metabolism and weight loss. CLA has recently been shown to increase the activity of an enzyme (called lipoprotein lipase) that breaks down fat. In another study, a group of Scandinavian researchers gave approximately 4 grams of CLA each day to over 150 overweight men and women. After one year, the participants taking CLA lost an average of 9% body fat without changing their lifestyle or eating habits. Imagine how much fat they would have shed if they added a little exercise and watched what they ate!

CLA isn’t a quick fix for fat loss. Its effects on the metabolism are subtle and results take time. However, CLA is one of very few compounds (supplement or drug) that is shown in research to speed the fat loss process. According to all the research, a dose of 4 grams of CLA each day will enhance fat loss, particularly in people that perform vigorous exercise and follow a calorie-restricted diet.

Source: Am J Clin Nutr 79, 2004
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Fri Sep 05, 2008 7:09 pm

Again, compelling research for CLA:

CLA is an essential fatty acid supplement that is shown in several studies to speed fat loss and promote an increase in muscle mass. However, a recent study has revealed yet another benefit from supplementing with CLA

Aging and years of intense exercise can cause inflammation that breaks down the cartilage that surrounds bones and lubricates joints. Intense exercise can produce inflammation that provides an imbalance between repair (anabolic) and breakdown (catabolic) of tissue. High levels of prostaglandins and nitric oxide produced during exercise also contribute to cartilage breakdown.

However, a recent study by scientists at Texas University has found that CLA reduced prostaglandin and nitric oxide levels and suggest that CLA may help prevent cartilage deterioration. This finding is just another good reason for lifters to make sure they obtain enough CLA in their diet.

Source:The Journal Lipids 39;161-166, 2005.
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Mon Sep 08, 2008 9:50 pm

How can you go wrong with this one?

Yet another long term study has shown that supplementation with Conjugated Linoleic Acid (CLA) is a safe and effective supplement that provides effective fat loss in adults. This study lasted 24 months and aside from monitoring CLA’s effects on body composition it focused on evaluating the safety of this supplement by using clinical chemistry analyses and asking the participants to report any adverse effects.

After an initial 12 month randomized, double-blind, placebo-controlled trial with CLA, 134 of the 157 participants continued this study for another 12 months. The CLA supplemented subjects continued taking 3.4 grams of CLA per day in capsule form. The end point assessments demonstrated that changes in body composition were not related to diet and/or exercise training. CLA supplementation provided no ill effects and maintained the significant reduction in body fat experienced by these participants in the earlier trial.

These results suggest that 1000mg of CLA taken several times a day, not only helps shed body fat, but it’s also safe and effective for keeping that unwanted fat off over the long term.

Source: Journal of Nutrition, 135: 778-784, 2005
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Mon Sep 22, 2008 4:28 am

Conjugated linoleic acid (CLA) is a compound shown in many animal and human studies to improve body composition either by maintaining lean muscle mass or enhancing fat loss. CLA is also a powerful antioxidant that may help protect against a variety of cancers. Other studies suggest that CLA helps improve glucose metabolism and leptin levels to help a person stay lean once the fat comes off.

However, a recent study has reported that CLA may also enhance fat loss by reducing hunger and increasing satiety (the feeling of fullness) in response to meals. Researchers from Holland have shown that a diet rich in CLA helped people eat less food and feel more satisfied from consuming smaller meals. This finding could make CLA a dieters dream. This is just another one of many research-based health benefits from CLA; an amazing supplement.

Source: Physiol Behav, Dec, 2004
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Mon Sep 22, 2008 4:33 am

Every month it seems as though a new study is uncovering another benefit from taking CLA (conjugated linoleic acid). Previous research in humans suggests that CLA aids in fat metabolism. Fat is an important energy fuel source. Theoretically, better fat metabolism would provide more substrate to fuel exercise.

A recent study in rodents has shown that CLA increased the use of fat as a fuel source. Not only that, it also increased exercise endurance capacity by 25%. These results were obtained in rodents and need to be confirmed in human trials. However, CLA is already shown to improve fat metabolism in human trials, so the capability of this supplement to boost endurance exercise performance in humans is a real possibility.
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Thu Oct 09, 2008 4:07 am

Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid derived from the essential fat linoleic acid. CLA possess potent antioxidant qualities, however, studies with animals (rodents, pigs, and chickens) also demonstrate its effectiveness for reducing body fat and increasing lean mass. Human trials have provided more equivocal results in terms of body composition changes.

One reason for these inconsistent results in human studies has probably been the lack of a structured exercise program incorporated into the trial. This rationale served as the basis for a recent study that examined the effects of CLA supplementation during a resistance training program in a group of healthy people.

In this study seventy-six resistance-trained participants were randomized to receive CLA (5 grams per day) or placebo for 7 weeks while training 3 days per week. Seventeen of the subjects then crossed over to the opposite group for an additional 7 weeks. This study assessed strength gains, body composition and markers of muscle catabolism (breakdown) before and after treatment with CLA.

After the first 7 weeks, the group given CLA demonstrated a gain in lean (muscle) mass that was seven times greater than the placebo group (+1.4 vs +0.2 kg for CLA vs placebo).

Supplementation with CLA also resulted in reduction in fat mass (-0.8 vs +0.4 kg) unlike the placebo-treated group. The group given CLA also showed a reduction in a key indicator of muscle protein breakdown. All other assessments provided equivalent results. However, another interesting finding was the males given CLA demonstrated significantly greater gains in bench press strength.

CLA appears to help reduce the catabolic effect of training. This is at least one reason why supplementation with CLA during resistance training is effective at improving body composition (more muscle, less body fat).
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Wed Oct 22, 2008 8:33 pm

A meta-analysis of human studies has concluded that conjugated linoleic acid (CLA) is highly effective for reducing body fat.

A meta-analysis is a study of all the studies that have been completed on a particular topic. It involves the statistical treatment of all the data to present a clear summation of the information on a particular topic.

This meta-analysis, by researchers at the University of Wisconsin School of Medicine and Public Health, identified all studies in which CLA's potential was tested in double-blinded, placebo-controlled trials and involved body composition assessment.

Results showed that CLA significantly improved the rate of fat loss. The median effective dose per day was deemed to be close to 4 grams of CLA per day.

Remember that most of these studies weren’t completed on bodybuilders or others that are highly disciplined with their exercise training and diet. CLA should be even more effective in these people
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Re: Research - Conjugated Linoleic Acid: CLA

Postby Canuck Singh » Sat Oct 25, 2008 10:35 am

Creatine and CLA
The average adult in the United States can expect to gain approximately 1 pound of fat every year as they age from 30 to 60, and they’ll lose about a half pound of muscle each year over that same time span.

That’s a 15 pound loss of muscle and a 30 pound gain in fat!

Getting old sucks!


However, every week new research is showing us how to stay strong, lean and muscular as well as beat most of the illnesses associated with aging. For example, a recent study has shown that in older adults, intense weight training combined with creatine monohydrate and conjugated linoleic acid (CLA) dramatically boosted muscle mass and strength gains.

This study involved a group of older adults (over 65 years) who undertook 6 months of structured resistance training during supplementation with creatine monohydrate (5grams/day) + CLA (6grams/day) or placebo.

The scientists reported that all the participants benefited from pumping iron, they all showed significant improvements in strength and functionality. However, those who took the creatine-CLA supplement combo enjoyed significantly better results in terms of muscle mass, strength and endurance as well as a larger drop in percentage of body fat, compared to the placebo group.

Source: PLoS ONE, the peer-reviewed online journal of the Public Library of Science.
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