Healthy Heart Genes

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Healthy Heart Genes

Postby Canuck Singh » Thu Oct 09, 2008 3:57 am

The cardio-protective effects of exercise training are well known. Studies clearly show that moderate to intense exercise training (above 60% VO2max) increases the strength and efficiency of the heart that results in better cardiac performance.

To improve our current knowledge of the molecular mechanisms underlying exercise-induced cardio-protection, a group of Italian scientists examined the gene expression (mRNA) profiles of rodents hearts before and after a 14 week exercise training program.

Results obtained from real-time PCR and Western blot analyses clearly showed a training-induced up-regulation of a gamut of mRNAs and proteins. Including genes thought to be associated with reduced DNA damage, tissue inflammation and improved glucose metabolism.

Source: European Journal of Applied Physiology, 2007
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