Green Tea - EGCG

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Green Tea - EGCG

Postby Canuck Singh » Tue Aug 19, 2008 4:31 am

Can you say epigallocatechingallate (EGCG)?

Green tea's ability to fight cancer and provide other health benefits is even more potent than scientists initially suspected. A group of researchers have recently discovered that a component in green tea can shut down one of the key molecules in our DNA thought to trigger cancer.

Green tea has been linked for some time to strong anti-cancer effects as well as other purported abilities such as preventing rheumatoid arthritis, lowering cholesterol, and fat loss but scientists still do not know how the substance provides these benefits.

Initially, it was presumed that green tea’s antioxidants prevented free radical damage in cells. However, a research team at Rochester's Environmental Health Science Center, have discovered that green tea’s health benefits may be achieved via an even more potent mechanism.

Compounds such as tobacco smoke and other environmental pollutants manipulate molecules in our DNA that “switch on” cancerous mutations. Green tea contains compounds called epigallocatechingallate (EGCG) and epigallocatechin (EGC) that bind to the aryl hydrocarbon (AH) receptor on these cancerous mutations. Thus inhibiting proliferation and essentially stopping cancer dead in its tracks.

The EGCG and EGC are flavonoids similar to that found in broccoli, cabbage, grapes and red wine. These chemicals were shown to shut down the AH receptor in cancerous mouse cells, and early results indicate the same is true in human cells as well.

The AH-inhibiting effects of green tea become evident when EGCG and EGC reach levels typical of those found in a cup of green tea. This could help explain why some survey studies show that people who drink green tea are less likely to develop cancer.

Drinking green tea on a regular basis may well be the most effective (and economical) safeguard against one of the biggest killers known to man.

Chemical Research in Toxicology 16;7:865 – 872, 2003.
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Re: Green Tea - EGCG

Postby AmardeepSingh » Wed Aug 20, 2008 10:17 pm

I thought green tea had caffeine so I stopped drinking it. Found out the other day that it doesn't :)
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Re: Green Tea - EGCG

Postby Canuck Singh » Wed Aug 20, 2008 10:30 pm

AmardeepSingh wrote:I thought green tea had caffeine so I stopped drinking it. Found out the other day that it doesn't :)

Green Tea does have caffeine in it.

Caffeine is shown in research to be a safe and beneficial compound:
ephedrine-caffeine-t111.html
ephedra-caffeine-t142.html
caffeine-good-for-ya-or-not-t110.html

Watch out for a article that weans through the facts and fallacies of caffeine...
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Re: Green Tea - EGCG

Postby AmardeepSingh » Tue Aug 26, 2008 9:40 pm

World Anti-Doping Agency - Banned List topic
Although they've lifted the ban, there must have been a reason why it was on there
it enhances performance, so it's like a drug?
I prefer not to drink caffeine 1) because I'm really sensitive to it and 2) because I see it as a drug
The green tea that I started drinking has no mention of caffeine in the ingredients
it's called Arizona Green Tea with Ginseng and Honey
You can get a 42oz bottle from the dollar store or a tall 16oz can for about 99cents from most gas stations
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Re: Green Tea - EGCG

Postby Canuck Singh » Tue Aug 26, 2008 11:33 pm

I understand, and I am not going to attempt to sway your opinion, but the IOC, the FDA, are not really on top of the research and certainly are not the be all and end all of understanding natural food supplements versus synthetic anabolic agents with side effects.
If we go by the logic that things are not natural, then we should avoid 99.9% of medicine. But yet medical culture and pharmacy companies with millions and billions of dollars vested in you getting sick, see no problem in keeping the facts from the average person.
There are some ludicrous companies and organizations that would claim creatine is a steroid, ingestion is unethical, and that it is a drug with side effects.

All unsubstantiated claims. Creatine is found naturally in some foods and so is caffeine. Aspirin or salicylic acid is also found as a natural herb (willow bark), yet we do not attest to its consumption, even though the synthetic version is responsible for over 14 000 deaths each year.

Here is a paper that backs up Creatine's safety and efficacy, it is a world renowned review:
Buford, Keider, Stout (2007) - Position Statement on Creatine.pdf


I will post something similar on caffeine, showing its benefits in reducing insulin dependence, enhancing heart health, amongst other benefits.
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Re: Green Tea - EGCG

Postby Canuck Singh » Sun Aug 31, 2008 11:48 pm

Previous studies have found that the major polyphenol in green tea extract, epigallocatechin gallate (EGCG) may protect internal organs against cancer. The effects of EGCG are so powerful, the results of a new study suggest that EGCG will soon be used to treat esophageal adenocarcinoma; one of the fastest growing cancers in western countries.

A team from the Harvard Medical School has reported that EGCG inhibited the growth and reproduction of cancer cells (SEG-1 and BIC-1) associated with Barrett’s esophagus; a condition caused by stomach acid creeping back up from the stomach. The acid damage causes the cells lining the esophagus to change and this raises the risk of esophageal cancer by 30 to 40 times.

The results of this research suggest that supplementation with EGCG may not just be a valuable compound that helps protect against cancer, it may also be used to treat some forms of cancer. Don’t forget that other studies have shown that EGCG also enhances fat metabolism. EGCG is an amazing compound that every health-conscious person should incorporate into their nutrition program.
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Re: Green Tea - EGCG

Postby Canuck Singh » Thu Oct 09, 2008 4:00 am

Epigallocatechin-3-gallate (EGCG), an extract from green tea, has recently been shown to inhibit the production of inflammatory molecules associated with joint pain, degeneration and arthritis.

Scientists at the University of Michigan utilized synovial fibroblasts which are cells that form a lining of the tissue surrounding the joints. These cells were taken from patients with rheumatoid arthritis. The fibroblasts were subsequently cultured in a growth medium and some of them were incubated with EGCG. A pro-inflammatory cytokine (IL-1beta) was then added to the culture medium. IL-1beta is an immune system protein that plays an important role in causing joint destruction in people with arthritis.

Results showed that when cells were stimulated with IL-1beta, a cascade of events occurred that resulted in production of the bone-destructive molecules (called interleukin-6 and cyclooxygenase-2). However, when the cells were incubated with EGCG, the production of these destructive molecules was not observed.

Work is ongoing with regard to the inhibitory role of EGCG in joint cartilage arthritis. Further studies will assess whether EGCG can provide similar therapeutic or preventive effects against arthritis. Nevertheless, these results are a very promising step in the search for therapies for the joint destruction in millions of people that suffer from arthritis.

Source: Experimental Biology Meeting, Washington, 2007.
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Re: Green Tea - EGCG

Postby Canuck Singh » Sat Oct 25, 2008 8:14 pm

The liver performs thousands of essential functions everyday, from detoxifying pollutants to producing those all-important growth factor hormones. A healthy liver is essential to building a lean, muscular physique. The results of a new study suggest that green tea extract may not only help you get lean, it may also maintain the health of this key organ.

At the end of this study, the researchers found that obese mice given green tea extract in their diet had 23 to 25% less body fat than the obese mice fed a non-supplemented diet. Another interesting finding was observed in a group of mice that were not obese. That is, regular weight mice that were given green tea extract showed 11 to 20% less body fat than their counterparts on a non-supplemented diet.

Measurements of liver damage such as the blood enzymes alanine aminotransferase and aspartate aminotransferase, showed that green tea extract provided a preventative effect against liver damage, as high as 30 to 40%.

More studies are underway to define exactly how green tea extract can help shed body fat and promote a healthy liver.
Source: Journal of Nutrition 138: 323-331, 2008.
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Re: Green Tea - EGCG

Postby Canuck Singh » Sun Oct 26, 2008 10:14 am

According to a recent study, regular consumption of green tea boosts cardiovascular health.

This small study on 14 healthy adults found that the beneficial effect was related to green tea’s polyphenols. The most bioactive polyphenols found in green tea is epigallocatechin gallate (EGCG). This polyphenol has been linked to improved fat metabolism, central nervous system function and protection against various forms of cancer. This study indicated green tea’s benefits resides in its ability to improve the function of endothelial cells, which are the cells that line the walls of blood vessels.

Source: European Journal of Cardiovascular Prevention and Rehabilitation , July 2008
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Re: Green Tea - EGCG

Postby Canuck Singh » Sun Oct 26, 2008 10:23 am

Supplementing with the green tea compound EGCG appears to reduce physical and mental fatigue, suggests research from Japan.

Using an animal model, oral intake of EGCG for five days reduced levels of oxidised species related to fatigue.

This green tea extract has already been linked with protective effects against Alzheimer's and certain cancers, improve cardiovascular and oral health, as well as promote fat metabolism. The positive results on reducing fatigue in this study, need to be replicated in human trials. However, the hypothesis is very plausible and the data from this research is positive.

Source: Nutrition, June 2008
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Re: Green Tea - EGCG

Postby Canuck Singh » Sat Nov 15, 2008 4:14 pm

Indeed, research has shown a green tea extract may help in controlling body composition by activation of thermogenesis or fat oxidation. Just like ephedra does.

A report published in the American Journal of Clinical Nutrition (70:1040-1045) by Dr Abdul G. Dulloo at the University of Geneva in Switzerland, demonstrated that subjects given great tea significantly increased their 24-hour energy expenditure (theromgenisis).

In this double blind trial, 10 men received either the green tea extract, caffeine or a placebo. These thermogenic effects appear not to be due to the caffeine content in green tea, as subjects receiving similar amounts of caffeine displayed no changes in energy expenditure, norepinephrine secretion or urinary nitrogen excretion. Green tea does contain a high amount of catechin polyphenols that inhibit the breakdown of norepinephrine, this prolonged activation may be the cause of the enhanced thermogenesis.
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Re: Green Tea - EGCG

Postby Canuck Singh » Tue Feb 03, 2009 2:04 pm

Human study: weight loss slightly faster with green tea

A green tea-based soft drink helps fat people to lose weight a tiny bit more quickly, write researchers from the Kao Corporation in the Journal of Nutrition. Green tea accelerates weight loss in the abdominal area in particular.

EGCG
The researchers gave 65 overweight people half a litre daily of a soft drink based on green tea. The slightly fewer people in the control group were given a soft drink that tasted the same. The test subjects did a moderate cardio work out at a gym three times a week, under supervision.

The product contained 40 mg of caffeine. The placebo drink also contained the same amount of caffeine. The green tea drink contained a total of 625 mg of catechins. An average cup of hot green tea contains about a hundred milligrams of catechins, but strong tea can contain up to one hundred and fifty milligrams.

The researchers monitored the weight loss of the test subjects over a period of twelve weeks:
- The control group lost about one kilogram of bodyweight; the green tea group lost a little over two kilograms. The difference was not quite statistically significant.
- What was significant was the effect on the total abdominal fat area and the abdominal subcutaneous fat area.

This is not the first study of its kind published by Kao – one full of promise, but which ultimately contains few hard results.

The problems with the product tested is not that green tea doesn’t work. Green tea does work. The problem is that you need an awful lot of it, and even then the effect is modest. An effective slimming stack based on green tea is 300 mg EGCG and 300 mg caffeine per day. EGCG is the most effective substance in green tea. The Kao product contains 214 mg of EGCG.


Sources:
J Nutr. 2009 Feb;139(2):264-70.

More:
CLA and EGCG promising super stack in small trial 02.02.2009
Green tea contains insulin booster 08.11.2008
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Re: Green Tea - EGCG

Postby sophiecondamine » Sat Jul 30, 2016 5:29 am

It’s a good natural and nutritional way to lose weight and green tea helps our body to reduce the fats and its a very healthy way to lose weight.
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